My ivf Journey

醫院會不會搞錯精子?

要不要驗PGS?


2018年8月27日星期一

如何治疗患有严重地中海贫血症的孩子?来了解Saviour Siblings 计划




患有常染色体显性遗传或隐性遗传疾病的夫妇很有可能怀孕具有严重的遗传后果。 β地中海贫血是马来西亚和东南亚流行的一种此类疾病。

总结来说,地中海贫血是马来西亚的公共卫生问题。据估计,这个国家每年有350名婴儿出生,主要是依靠输血治疗地中海贫血。这个数字每年将累积增加,给患者和家庭带来巨大的社会和经济困难。

大多数重型地中海贫血患者都屈服于悲惨,痛苦和折磨的生活。他们的生活以医院环境为中心。定期输血,铁超负荷,全身衰弱和身体不健康损害了他们的生命。失去教育,就业,沮丧和绝望会增加他们的痛苦。


来自健康的HLA相容的骨髓供体或脐带血,优选来自兄弟姐妹的造血干细胞移植(HSCT)可能是β-地中海贫血患者恢复正常血细胞形成(造血)的最佳治疗选择或唯一可能的治疗方法。许多患者仍然无法接受这种治疗,因为难以在直系家庭和大家庭中找到HLA匹配供体。因此,患有非捐赠者的患者和没有捐赠者的患者可以从Savior兄弟姐妹计划(SSP)中受益。

Saviour Siblings 是通过体外受精而生的孩子,其组织(来自脐带血的HSC)将被捐赠,以便兄弟或姐妹将免于危及生命的遗传疾病。

超越常规植入前基因检测非整倍性(PGT-A)和植入前突变基因检测(PGT-M),Alpha生育中心现在提供植入前基因检测HLA(PGT-HLA),帮助父母怀孕一个孩子是与他们的兄弟姐妹的组织(HLA)匹配。在Saviour Siblings 的诞生期间,收获富含干细胞(否则被认为是废物)的脐带血并输注给垂死的儿童以恢复正常的血细胞形成。

Alpha生育中心是马来西亚第一个也是唯一一个IVF中心,它在胚胎活组织检查中提供基于NGS的高分辨率HLA基因分型,以选择染色体健康(PGT-A),无疾病(PGT-M)和HLA匹配的胚胎( PGT-HLA)为患病的兄弟姐妹。所有三个基因测试均在单个活检样本上完成。




简单来说,如果你的家庭有一位孩子有严重地中海贫血需要长期输血的话,你可以靠Saviour Siblings 计划生下一位孩子,并和你哪位患有地中海贫血的孩子的组织(HLA)匹配。等到Saviour Siblings 出世那一天,将他的脐带血输注给患病的兄弟/姐妹之后,他就可以以恢复正常的血细胞形成。以后不需要再输血过日子。



SAVIOUR SIBLING PROGRAMME (SSP) A New Lifeline – A Brand New Hope 
献给你来自Alpha 团队


想了解更多关于Saviour Siblings 疗程欢迎联络: http://www.wasap.my/60172552022


English version : http://blessingivf.blogspot.com/2018/08/how-to-save-your-thalassaemia-children.html?m=1

How to Save Your thalassaemia Children with SAVIOUR SIBLING PROGRAMME

SAVIOUR SIBLING PROGRAMME (SSP) A New Lifeline – A Brand New Hope 



Couples with autosomal dominant or recessive disorders have a significant chance of conceiving a pregnancy that has serious genetic consequences. Beta thalassaemia is one such disorder that is endemic in Malaysia and Southeast Asia.

Thalassaemia, in general, constitutes a public health problem in Malaysia. It is estimated that 350 babies are born each year in this country with blood transfusion dependent thalassaemia major. This number will cumulatively increase each year posing enormous social and economic hardships not only to patients and families but also to the government in ensuring optimal care for the existing population of thalassaemia major.


Most of the thalassaemia major patients succumb to a miserable, depressing and painful existence. Their lives are centred around the hospital environments. Regular blood transfusion, transfusion transmitted illnesses, iron overload, general debility and ill-health mar their lives. Loss of education, employment, depression and despair add to their miseries.



Haematopoietic Stem Cell Transplantation (HSCT) from a healthy HLA-compatible marrow donor or cord blood, preferably from a sibling, maybe the best treatment option or the only potential cure for patients with beta-thalassaemia to restore normal blood cell formation (haematopoiesis). Many patients remain unable to receive this treatment because of the difficulty of finding an HLA-matching donor within the immediate and extended family. Thus, patients with nonsibling donors and patient without donors may benefit from Saviour Sibling Program (SSP).


Saviour Siblings are children who are born through in-vitro fertilisation whose tissue (HSC from the cord blood) will be donated so that a brother or sister will be saved from the life-threatening genetic disorder.

Moving beyond routine preimplantation genetic testing for aneuploidy (PGT-A) and preimplantation genetic testing for mutations (PGT-M), Alpha Fertility Centre now offers pre-implantation genetic testing for HLA (PGT-HLA), to help parents conceive a child who is a tissue (HLA) match with their older sibling. During the birth of the saviour sibling, the umbilical cord blood which is rich in stem cells (otherwise considered a waste material) is harvested and infused to the moribund child to restore normal blood cell formation.

Alpha Fertility Centre is the first and only IVF centre in Malaysia that offers NGS-based high-resolution HLA genotyping on embryonic biopsies to select embryos that are chromosomally healthy (PGT-A), disease-free (PGT-M) and HLA matching (PGT-HLA) for the sick sibling. All three genetic tests are done on a single biopsy sample





Article sharing from Alpha Fertility Website


Make your appointment today,you can contact me at : http://www.wasap.my/60172552022
Fill in form to apply a free voucher for First time visit :https://goo.gl/cDKCmP






2018年8月18日星期六

最新的ICSI 技术PIEZO,为什么要做ICSI ?


一直很想分享这个新的ICSI 技术给大家,
迟迟找不到时间写出来,
今天来给大家讲讲这个

压电式胞浆内单精子注射 (PIEZO-ICSI)

先说说做 ivf 试管,为什么要加ICSI ,原因就是现在很多男人的精子都欠理想,
透过ICSI 胞内精子注射技术,才能更好的让卵子和精子结合在一起。也属于人为的将精子放进卵子中结合。因为如果精子质数欠理想,怎么还可以让精子自己游进去卵子里呢,就是这个原因。


常规式的ICSI 是利用注射针将精子注射进卵子里,这个方式在卵子细胞被注射针穿透 透明带时会变形,
细胞膜穿孔的时机很难拿捏,明显可能伤害卵子细胞。




那么这个新的压电式胞浆内单精子注射 (PIEZO-ICSI)是一种先进的技术,可以减少对卵子的伤害,并于常规式的ICSI相比更能提高受精率。到目前为止,研究表显示电压式ICSI 具有最低的卵子降解率(1%)和最高的受精率(89%)

相对于传统的ICSI,压电式ICSI 使用较细的注射针尖,而注射针尖的顿的而非尖锐的,因此降低伤害卵子的可能性。



研究表明,压电式ICSI 并不影响卵子细胞骨架以及对卵目细胞在细胞分裂时,染色体不受影响。它也表面,从压电式ICSI 衍生的囊胚非整体率是与常规ICSI 类似。
所以选择做ICSI的时候,建议也添加这个PIEZO,费用不多于3百,





了解更多欢迎咨询:http://www.wasap.my/60172552022













2018年8月5日星期日

关于Day 3/Day 5 胚胎等级的分别

胚胎移植是试管婴儿流程中的一个非常重要的过程,但是很多人可能对于胚胎移植感到比较陌生,特别是有关于试管婴儿胚胎等级的划分,试管婴儿胚胎的质量是影响试管婴儿的成功率的重要因素。


  关于胚胎评级

  目前全世界的试管婴儿诊所胚胎等级划分标准并不统一,一般的AA级囊胚评级非常稀有,而美国好的试管婴儿医院,AA级的囊胚就相对比较常见。另外,有的诊所可能用“811”这样的评级法来描述评定第三天的胚胎,或者用8A来表示。

  卵子(单细胞)

  单细胞发育分裂

  胚胎(Embryo) 

  桑葚胚(morula) 

  囊胚(Blastocyst)

  一般来说,胚胎的移植或是冷冻要么发生在第三天要么发生在第五天。卵子刚取出来,只是单细胞,受精12-24小时后在培养液里发育并分裂,所以到第三天一般是4-8细胞的胚胎(Embryo)。而到第五天,大约发展成上百个细胞,此时胚胎也被称被囊胚(Blastocyst)。界于两者之间(一般是第四天),还有一个阶段叫桑葚胚(morula),因桑葚胚比较难评级,一般不做评级,所以一般胚胎评级都是发生在D3和D5阶段。

  第三天(D3)胚胎评级




  一般来说,胚胎评级跟以下几个因素有关,胚胎的细胞数、分裂后细胞的均匀程度以及碎片化程度。这里先说一个比较常见的分级法,是从一级到四级,一级最好,四级最差,胚胎级别描述:


  一级 细胞分裂均匀; 没有碎片

  二级 细胞分裂均匀; 有少许碎片

  2.5级 细胞分裂大致均匀,有些碎片

  三级 细胞分裂不均匀; 没有碎片或有些碎片

  四级 细胞分裂非常不均匀; 碎片比较严重


  这里要补充说一下为什么会有碎片。当胚胎受到自身原因或体外环境压力时,会产生DNA修复机制,排出对机体有害的细胞成分,导致碎片的生成。所以碎片越多的胚胎,生长潜力可能越差,这成了判断胚胎好坏的一个重要标志。


  一般一级和二级的第三天胚胎都是很不错的,三级的稍差但还可用。四级则不太有被移植的可能性。比如说你被告知第三天的胚胎是一个一级8细胞的,那么恭喜你,成功的可能性还是挺大的。当然,胚胎的好差还跟病人的年纪有关,同样的一级8细胞,年轻女子的染色体变异系数非常低,而年纪大的变异系数却相对高很多。


  有些诊所喜欢用罗马字I-IV来表达第三天的胚胎评级,有些喜欢用A-D来表达。其实参照的描述是差不多的。有些喜欢用三个数字来表示,比如D3的811,第一个数字是细胞数目(8个),第二个数字表达碎片多少(1是几乎没有),第三个数字是表达细胞形态(1为最佳),所以我们可以得知这个811是个几乎完美的第三天胚胎。



第五天(D5)囊胚评级

  根据囊胚腔的大小和是否孵化,将囊胚的发育分为六个时期。



  
  第1期:早期有腔室囊胚,囊胚腔小于胚胎总体积的1/2

  第2期:囊胚腔体积大于或等于胚胎总体积的1/2

  第3期:完全扩张囊胚,囊胚腔完全占据了胚胎的总体积

  第4期:扩张囊胚,囊胚腔完全充满胚胎,胚胎总体积变大,透明带变薄

  第5期:正在孵出的囊胚,囊胚的一部分从透明带中逸出

  第6期:孵出的囊胚,囊胚全部从透明带中逸出

  处于3至6期的囊胚,还需对其内细胞团和滋养层细胞进行质量分级。
  1

  内细胞团分级

  A级,细胞数目多,排列紧密;

  B级,细胞数目少,排列松散;

  C级,细胞数目很少。

  2

  滋养层细胞分级

  A级,上皮细胞层由较多的细胞组成,结构致密;

  B级,上皮细胞层由不多的细胞组成,结构松散;

  C级,上皮细胞层由稀疏的细胞组成。


  三个数字结合起来,就能大致知道囊胚的形态。比如4AA囊胚,它是一个细胞排列紧密、几乎没有碎片、还没有孵出的囊胚,通常被认为最适合移植的囊胚。5AA或6AA,虽然看起来比4AA的更有发育潜能,但因为部分细胞已从透明带逸出,在实质移植操作中反而不如4AA的囊胚更好。


  其实还有D级的分级。但一般到了D级质量就无法移植,所以我们只谈到C级。我们已知道,每个诊所接纳的最低级别不太一样,比如有的接纳的最低级别囊胚是3CC,低于此级别的,则没有移植的意义。此外客人卵子的数量也会影响诊所对囊胚的取舍,有的客户胚胎比较多,3BC这样的级别可能就舍掉不用了,而对卵少的客户来说,一个3BC也许就能活产一个孩子!

  有些胚胎发育慢,到第六天(D6)甚至第七天(D7),才发育成囊胚。因此,除了三个数字以外,囊胚的天数还是判断其发育潜能的重要指标。通常来说,D5的最好,D6的次之,D7的再次之。再晚一点发育的,基本上被认为没有什么发育潜能。D7形成的囊胚虽然慢了点,移植成功率也低了点,但是能挺到这个时候还没有“光荣牺牲”,也已经相当优秀了,所以也不要轻言放弃。





2017年12月18日星期一

My IVF Journey Interview Video


My IVF journey interview video by MHTC ❤️
🤗Thank you Malaysia Healthcare Travel Council 👍
我们替MHTC拍的访问短片终于拿到了😍
看到剪辑好的视频,感动了很久。。。
也让我可以做个纪念❤️
在这些年来,前来和我聊天的姐妹也不少,
很多也因着我的分享和建议,
提起勇气去接受这个疗程而成功怀孕了👏
真的很为她们感到高兴!
很多还在努力的途中,
祝福你们都能成功,
希望把这一份感动和勇气继续分享下去✌️


2017年12月17日星期日

Reason to Choose a Best IVF Centre





INVESTING IN YOUR SUCCESS




IVF Treatment for Infertility
Fertility treatment is amongst one of the most challenging medical treatment to understand as it is an elective procedure with an average success rate of around 50-50.

At Alpha Fertility Centre, however, all the odds are tipped in your favour. From investing in revolutionary technologies to continuous training and Research & Development, every investment is a calculated decision to increase your chances of bringing home a bundle of joy.

With unmatched IVF protocols and international clinical standards, you need not look far to enjoy success rates that are comparable with top IVF centres around the world.

It is no secret that IVF technology is an intensely delicate procedure, as it involves the fertilisation of sperm and oocytes. This means even the slightest change in the surroundings or the genetic makeup could make a difference in the fertility treatment’s success.
PGS to avoid unnomal blatocyst transfer



PREIMPLANTATION GENETIC TESTING
Preimplantation Genetic Testing is already a well-known procedure in many fertility centres, where embryos and/or blastocysts are screened and graded. Only normal embryos will be transferred into the woman’s womb, hence increasing chances of pregnancy and reducing rates of miscarriage. With the ION TORRENT TECHNOLOGY, Alpha is able to run PGS/PGD concurrently on a single platform from a single biopsy. This increases clinical pregnancy rates to 82.9% compared to other systems where the biopsy would be done at least twice, causing possible downgrade to a good embryo/ blastocyst.

Cryotec Freezing Tecnology with 100% survival rate (only at Alpha Fertility centre)

EMBRYO FREEZING

The freeze-thaw process is a crucial element in any IVF treatment, where extra oocytes and blastocysts are stored for future use. Since July 2013, Alpha has been using the proprietary CRYOTEC® Freezing Technology for all embryos and blastocysts, as it is the only method with a proven track record of 100% survival rate of embryos and blastocysts during the freeze-thaw process.


PIEZO-ICSI
While most fertility centres currently use Intra-Cytoplasmic Sperm Injection (ICSI) to introduce fertilisation, Alpha is the only centre in SEA that uses Piezo-ICSI. Piezo-ICSI uses a blunt, finer injection tip to introduce the sperm into the egg, hence the possibility of damaging the egg is reduced. This has proven to give better fertilization rate & healthier embryos through monitoring the morphological changes of the embryos.

TIME LAPSE & EMBRYOSCOPY
Alpha has also invested in the capability to visualize the progress of embryo development continuously from Day 0 to Day 7 by taking photographs every 5 minutes in the incubator. This allows embryologists to select only best embryos for transfer and increase IVF success rate.

These technologies and more are brought together under one roof to provide customization of treatment because no two couples are ever the same. Every couple is special – thus, Alpha Fertility Centre is committed to making each treatment plan one-of-its-kind.

PART OF THE CULTURE – CONTINUOUS R&D
R&D lies at the very heart of Alpha Fertility Centre. As a strong member of the international fertility fraternity, Alpha Fertility Centre enjoys access to the latest updates, knowledge and skills in fertility treatment.

Alpha Fertility Centre’s specialists also contribute to the pool of knowledge by conducting research prolifically. The results have been published in many international journals, or presented in international conferences, such as the Preimplantation Genetic Diagnosis International Society (PGDIS) Annual Congress, Congress on Asia Pacific Initiative on Reproduction (ASPIRE), and the annual Obstetrical and Gynaecological Society of OGSM (Malaysia ) Congress.

20 scientific papers were produced in 2016, whereas 15 scientific papers were produced in 2017. The commitment to the development of the science of fertility treatment is well-recognised by peers in the same industry. Internally, the centre also invests heavily in training and development for its doctors, embryologists and staff to optimize their skills and potential.

RESULTS THAT SPEAK FOR THEMSELVES
For patients on fertility treatment, all the technologies and skills are meaningless if they do not have the one single desired effect – pregnancy.

The centre’s high clinical pregnancy rate of 82.9% in 2016 was presented at the 24th Congress of Obstretrical & Gyneacological Society of Malaysia (OGSM), Kuala Lumpur, Malaysia. At the same conference, Alpha Fertility Centre also presented on a 100% post-thaw survival rates for embryos and blastocysts using the revolutionary Cryotec® freezing method.

A new technique showing that a mix in frozen blastocyst on Day 5 and Day 6 resulted in high clinical pregnancy rates of 71.4% was presented at the 6th Congress of the Asia Pacific Initiative on Reproductive (ASPIRE) in Jakarta 2016.

Another discovery in 2016 – the transfer of a single blastocyst aged less than 120 hours (from insemination to the time of embryo transfer procedure) produced outstanding clinical pregnancy implantation rates of 78.6% – was presented at the 15th International Conference on Preimplantation Genetic Diagnosis (PGDIS), in Bologna, Italy.





Make your appointment today,you can contact me at : http://www.wasap.my/60172552022

Fill in form to apply a free voucher for First time visit :https://goo.gl/cDKCmP








2017年12月10日星期日

对IVF试管疗程的各种疑问




#对IVF试管疗程的各种疑问

这个blog从我2014年准备做试管疗程写到现在,我女儿也快2岁了。当初只想把自己要面对试管的点点滴滴和心情在这里分享,也把自己的过程写一一记录下来希望可以让更多需要的人明白什么是试管疗程。很开心,期间也帮助了很多和我一样渴望当妈妈的姐妹达成愿望🤗真的觉得很开心👏👏👏

我知道还有很多姐妹还很迷惑,或者害怕,到底会不会痛,是不是很辛苦?其实生孩子会比这个痛😁 做试管疗程除了每天要打针,就是取卵后的那一天可能会比较不舒服,腹部会涨,好像月经痛的感觉。过了一天就会舒缓。然后到植入的阶段,也完全不痛的,植入是在完全清醒的状态进行,那是迎接你宝宝到来的一刻!当医生替我植入好的时候,我还对宝宝说欢迎你😀

参考➡️试管疗程如何进行 https://goo.gl/KJxeVs

经常也会遇到姐妹说,我很想当妈妈,但是我老公不想做试管,不想去检查,不想去了解,不和我沟通,认为他没有问题,不想浪费钱等等。其实听见这样的问题,心里也替她们难过。怀孕就是两个人的问题,一个家庭有了孩子才会更圆满。所以当老公的,要学会去体谅太太想要当妈妈这个心愿,她也只不过想给你生个像你一样的孩子吗?要知道女人的生育时间宝贵,一定要认真面对和看待这件事情。现在的技术真的很发达了,陪太太预约检查找出问题,完成太太的心愿吧。#老公的支持很重要

说到费用,是的,很贵,不便宜。2万多,每次有姐妹问我,请问你做疗程花了多少钱?我说2万3,哇 那么贵!是的,我第一次去询问疗程的时候,也是觉得,哇!原来要花那么多钱!到底老公会不会答应?我真的很想要孩子,所以就和老公商量。后来慢慢去消化一下,去了解各种收费细节,所用的技术。再从每家医院去分析,打价,好像菜市买菜那样,要比价钱。为了不让老公觉得有负担,却又能够让我尝试做一次试管,我就跟我老公说,我找到更便宜的,要不要去看看🤔结果他回答我说,现在是要打针做疗程,你一定要找最好的,不要找最便宜的,找好的希望可以一次成功😥听见他这么说,我觉得很安慰。因为他在支持我做这件事。让我觉得更有信心去做疗程,老公的支持真的很重要。既然决定要做,就找合适的医院来做。

还有最常听见的问题是"2万包成功吗?"
其实不包成功的,就像你进医院做手术一样,就算是小手术,医生也不会说100%成功对吗?所以找一家技术好的医院,每个环节的成功率都会提高一些,现在的健康囊胚移植已经有高达70%的成功率了。你还需要把自己的身体调理好,至少3个月时间来调理,你可以吃维他命,中药粉,做运动。
可以参考我之前的调理方式http://goo.gl/J0m75L

我是觉得,#生命无价,#天伦之乐更加无价。
如果我当初不决定去做疗程,#今天可能还是我们夫妻两人在过日子而已。可能我每天会带着遗憾的去过,因为年纪大了,不是你有钱说要做就能做了。所以各位夫妻们,好好去看待想要结婚生子这件事。祝福大家❤️

如果想了解更多我做的疗程,随时可以找我聊一聊😊

📲找我聊一聊:m.me/ivfjourney2015

如果你希望直接预约去检查,这里也有一张voucher可以免费送给你用。 是可以到Alpha, Kota Damansara 试管中心检查用的,到这里填表格就可以:https://goo.gl/cDKCmP

这里有我做试管的过程:
➡️我的IVF试管过程:https://goo.gl/QRqHG5
➡️取卵过程:http://goo.gl/8sDmm6
➡️植入过程:http://goo.gl/nvJyCm
➡️成绩揭晓:http://goo.gl/2pDw7U
➡️试管前调理:http://goo.gl/J0m75L
➡️请认真看待想要怀孕这件事:https://goo.gl/roiZEp
➡️老公写的文章,从老公的角度看试管疗程
IVF Journey, A Husband’s Perspective : https://goo.gl/GCfseS

➡️欢迎追踪我女儿奥莉的脸书:https://www.facebook.com/oliviababylove/


#ivfmalaysia #试管婴儿 #ivfjourney2015 #ivfblog #ivf #我的ivf试管婴儿の日记
#奥莉妈咪